Tildox AVZ POWDER FOR ORAL USE

Product benefits:

• Good solubility in water of any hardness.
• Synergistic action of two bacteriostatic agents.
• A wide range of antimicrobial action (Gr+, Gr-, mycoplasma, chlamydia, rickettsiae).
• Highly effective in respiratory diseases and mixed infections.
• Low toxicity.

Chemical composition and pharmacological properties

1g of Tildox contains 100 mg of doxycycline hyclate, 100 mg of tylosin tartrate as the active ingredients, and sodium benzoate and sucrose as the
excipients.
Tildox belongs to the pharmacotherapeutic group – tetracyclines in combination. Doxycycline is a semi-synthetic antibiotic of the tetracycline group, active against gram-positive and gram-negative microorganisms, including Bordetella spp., Campylobacter spp., Escherichia coli, Haemophilus spp., Pasteurella
spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium perfringens, Chlamydia spp., Rickettsia spp., as well as Mycoplasma spp.
The mechanism of the bacteriostatic action of doxycycline is associated with inhibition of the activity of enzymes which catalyze binding of aminoacetyl-
RNA to ribosomal acceptors, which disrupts protein synthesis and death of a microbial cell.
Tylosin is an antibiotic from the macrolides group, active against most gram-positive and some gram-negative bacteria, including Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp., Clostridium spp., Pasteurella spp., Erysipelothrix spp., Fusobacterium spp., Spirochaetes spp., Leptospira spp., Treponema hyodysenteriae, Actinomyces pyogenes, Haemophilus pertussis, Moraxella bovis, Neisseria spp. The mechanism
of the bacteriostatic action of tylosin is associated with blocking of the protein synthesis of a bacterial cell by combining with the 50S ribosomal
subunit.
When administered orally, antibiotics are well absorbed in the gastrointestinal tract and penetrate into most organs and tissues of an animal, reaching
maximum concentrations in blood serum in 1.5–2 hours.

Indications

Tildox is prescribed for therapeutic and therapeutic-preventive purposes to pigs and poultry in gastrointestinal and respiratory diseases of bacterial
origin, including pasteurellosis, mycoplasmosis, colibacteriosis, bordetelliosis, salmonellosis, dysentery, enzootic pneumonia and other infections, the
causative agents of which are sensitive to doxycycline and tylosin.

Contraindications

It is forbidden to use Tildox to the laying hens, as well as to animals with severe liver and kidney dysfunctions. Contraindication to use of the medicinal
product is the individual hypersensitivity of animals to its components. The medicinal product is not recommended for use during pregnancy and lactation. The medicinal product should not be used in conjunction with muscle relaxants, bactericidal antibiotics, mineral supplements and medicinal products containing salts of calcium, magnesium, iron and aluminum due to a possible decrease of the antibacterial effect.

Dosage and administration

Tildox is used:
• for pigs in the mixture with food or water for drinking, individually or by the group method, at a dose of 1 g per 10–15 kg of animal weight or 1 g of the medicinal product per 1 liter of water daily for 3–5 days;
• for poultry with water for drinking or with feed by the group method at a dose of 0.5–1 g per 1 liter of water for drinking or 0.5–1 g of the medicinal product per 10 kg of poultry weight daily for 3–5 days.
With the group method of use, poultry and pigs should receive only water or feed containing medicinal product during the treatment period. The
treatment solution or feed is prepared daily.
In case of the group use of the medicinal product with water for drinking, calculation of the stock solution amount with the use of a medicator is carried
out as follows:
А. The amount of the medicinal product (Q) in g for 1 day of treatment is calculated by the formula:
Q = N x P x Po x 100/Cm (in %), where N is the number of animals to be treated; P is the average weight of an animal, kg; Po is the therapeutic dose of the active substance preparation, mg/kg; Cm is the concentration of the active substance in the preparation in %.
B. The amount of the stock solution (V) for 1 day of treatmentis calculated by the formula:
V = С х R (in %)/100, where, С is daily water consumption in L; R is the medicator’s regulator in %.
The measured amount of the medicinal product (Q) is dissolved in the calculated amount of water (V) (preferably t = 20–30 °C) with intensive stirring for 5–10 minutes. If necessary, you can add a compatible solvent (acidic or alkaline depending on the water pH) or increase stock solution amountby increasing the medicator’s dosage. 30–45 minutes after the preparation commencement, the stock solution is ready for use.

Adverse events

When using the medicinal product for young animals during the period of tooth growth, change of the enamel color is possible. Pigs can develop allergic
reactions to tylosin in the form of mild edema of the rectum and anus, erythema, pruritus and respiratory phenomena, which quickly resolveafter medicinal product discontinuation.

Storage

The medicinal product shall be stored in a place protected from moisture and direct sunlight, separately from the foodstuff and feed, at a temperature from 0 to 25 °C. When stored according to requirements, the shelf life in the closed manufacturer’s package is 2 years since the production date, after the first opening of the package – no more than 3 months.

Pharmaceutical form

The medicinal product is released packaged in 1 kg in the polymer buckets of appropriate capacity with tamper-evident lids.