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Colistin 12 mln AVZ POWDER FOR ORAL USE

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1-kg, 5-kg
1-kg, 5-kg
Application :

Antimicrobial preparation to treat pigs and poultry

Release form :

1-kg polymeric cans, or 5-kg polymeric buckets sealed with tamper-evident lids; 5- and 50-g composite sachets.

Product benefits:

  • As the drug slightly absorbs in systemic circulation, it does not demonstrate a toxic effect on liver and kidneys.
  • Thermostable preparation suitable to be administered with food
  • Short-term safety interval
  • Efficient against microorganisms resistant to fluoroquinolones, betalactams, aminoglycosides, etc.

Chemical composition and pharmacological properties


1 g contains 12,000,000 IU of colistin sulfate (equivalent to 500 mg) as an active ingredient. Colistin sulfate (i.e., the drug ingredient) affects a number of gram-negative microorganisms including Escherichia coli, Pseudomonas aeruginosa, Aerobacter aerogenes, Corynebacterium diphtheriae, Klebsiella spp., Proteus spp., and Salmonella spp.
The mechanism of bactericidal colistin action is associated with an effect on plasma membrane permeability leading to death of microorganisms.
When administered orally, colistin is slightly absorbed in gastrointestinal tract. It does not accumulate in organs and tissues. Also, it is not affected by digestive enzymes. Finally, it has an antimicrobial intestinal effect. It is excreted unchanged, mainly, in urine and feces.
In terms of health effect, this product is a moderately hazardous substance (Hazard Category III as per GOST 12.1.007-76).

Indications


To treat and to prevent pigs and poultry with colibacillosis, salmonellosis and other bacterial gastrointestinal diseases caused by gram-negative microorganisms susceptible to colistin.

Contraindications

Individual hypersensitivity to the drug ingredients. Do not use in combination with ampicillin, cephalosporins and aminoglycoside antibiotics.

Dosage and administration


Administer with drinking water or food in an individual or groups manner in the following daily doses:
• pigs – 0.6-0.8 g of the drug per 100 kg of body weight;
• poultry – 50-75 g of the drug per 1000 l of water (3.75-5.6 mg of colistin sulfate per 1 kg of body weight).
The treatment course is 3 days. In case of salmonellosis, the duration is 5 days.
Prepare medical solution of the drug every day. Mix thoroughly until the powder dissolves completely.
When used with food, mix an appropriate dose of the drug with a daily food amount. Since Kolistin 12 mln AVZ is a thermostable product, it cam be included in food whose manufacturing process involves a short-term heat treatment.
During the entire treatment, poultry and pigs must receive only water or food containing the drug.

Adverse events

Adverse events and complications are not generally observed in case of administration as per this package insert. In case of individual hypersensitivity and allergic reactions, withdraw the drug and start a symptomatic treatment.

Special warnings

Slaughter pigs and poultry in 24 and 48 hours after the last drug administration, respectively. Consume laying hens' eggs without restrictions.
Meat of compulsorily slaughtered poultry and pigs obtained before termination of the stated period can be used to feed fur animals.

Storage

Store in a closed original package at 2-25°С. Protect from direct sunlight and moisture.

Pharmaceutical form

Available in 1-kg polymeric cans, or 5-kg polymeric buckets sealed with tamper-evident lids; 5- and 50-g composite sachets.
The sachets can be available in cardboard packs containing 1, 2, 3, 5 or 10 pcs each.


The information provided in this catalog is for reference only. There may be some changes in the characteristics, packaging and packaging of products.

AVZ reserves the right to make such changes without notice. You can get full information about the updated products from your personal manager or your nearest AVZ dealer.

All drugs for veterinary use from this catalog may be contraindicated and when using it is necessary to familiarize yourself with the Instructions for Use.

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