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Tulamycin-AVZ

100 ml, 500 ml
Release form :

100 and 500 ml each in dark glass bottles of the appropriate capacity, capped with rubber stoppers, reinforced with aluminum or aluminum-plastic caps.

Product benefits:

  • An effective single-use drug
  • It retains the therapeutic concentration in the blood and lung tissues for a long time
  •   Does not have an irritating effect on tissues

Chemical composition and pharmacological properties

Tulamycin-AVZ is produced in two dosages containing in 1 ml as active ingredients tulatromycin - 25 mg or 100 mg and lidocaine hydrochloride – 10 mg, as well as excipients propylene glycol, citric acid and water for injection.

In appearance, the drug is a colorless or yellowish transparent liquid.

Tulamycin-AVZ belongs to the pharmacotherapeutic group - macrolides in combination.

Tulatromycin, which is part of the drug, has a wide spectrum of action against many gram-positive and gram-negative microorganisms, including Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, Haemophilus somnus, Haemophilus parasuis, Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae, Mycoplasma bovis, Moraxella bovis, Neisseria spp., Bordetella bronchiseptica.

The mechanism of bacteriostatic action of tulatromycin is based on the suppression of protein synthesis at the ribosomal level.

Tulatromycin is rapidly absorbed from the injection site, reaching a peak concentration in blood plasma 15-30 minutes after administration, and is slowly excreted from the body. The antibiotic accumulates in neutrophils and alveolar macrophages, resulting in its increased concentration in lung tissues.

It is excreted unchanged from the body by the kidneys; the half-life is 75-85 hours in cattle and 40 hours in pigs.

Lidocaine provides an analgesic effect of the drug.

Lidocaine belongs to amide-type anesthetics. It has a local anesthetic effect, stabilizing the membranes of neurons, reducing their permeability to sodium ions, which prevents the generation and conduction of nerve impulses. A similar effect is observed on the excitable membranes of the cells of the heart muscle and brain. Lidocaine is characterized by a rapid onset of action, high anesthetic activity and low toxicity. In lower concentrations, lidocaine has less effect on motor nerve fibers. When applied topically, it dilates blood vessels, does not have an irritating effect on tissues.


Indications

Tulamycin-AVZ is used for therapeutic purposes:

- cattle with bacterial respiratory infections caused by Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, Haemophilus somnus, Staphylococcus haemolyticus, Mycoplasma bovis, and infectious keratoconjunctivitis caused by Moraxella bovis and Neisseria spp.;

- pigs with bacterial respiratory infections caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis, Mycoplasma hyopneumoniae and Bordetella bronchiseptica.

Contraindications

A contraindication to the use of Tobramycin-ABC is an individual hypersensitivity of the animal to its components. In connection with the release of tulatromycin with milk, it is prohibited to use Tulamycin-AVZ to dairy cows whose milk is used for food purposes, as well as pregnant cows and heifers less than two months before the expected start of lactation (calving), if milk is planned to be used for food purposes.

Dosage and administration

Tulamycin-AVZ 25 mg / ml is administered to pigs once intramuscularly in the neck at a dose of 1 ml per 10 kg of weight (2.5 mg of tulatromycin per 1 kg of weight). When prescribed to pigs whose weight exceeds 40 kg, the dose is divided so that the volume injected at one point does not exceed 4 billion.

Tulamycin-AVZ 100 mg / ml is administered to pigs once intramuscularly in the neck at a dose of 1 ml per 40 kg of weight (2.5 mg of tulatromycin per 1 kg of weight). When prescribed to pigs whose weight exceeds 80 kg, the dose is divided so that the volume injected at one point does not exceed 2 million.

Tulamycin-AVZ 100 mg / ml is administered to cattle once subcutaneously or intramuscularly at a dose of 1 ml per 40 kg of weight (2.5 mg of tulatromycin per 1 kg of weight). When prescribed to cattle whose mass exceeds 300 kg, the dose is divided so that the volume injected at one point does not exceed 7.5 ml.

Adverse events

When using Tobramycin-ABC in accordance with this instruction, side effects and complications are usually not noted. With increased individual sensitivity of animals to the components of the drug and the appearance of allergic reactions, the use of the drug is discontinued and symptomatic treatment is carried out for the animal.

Special warnings

In connection with the release of tulatromycin with milk, it is prohibited to use Tulamycin-AVZ to dairy cows whose milk is used for food purposes, as well as pregnant cows and heifers less than two months before the expected start of lactation (calving), if milk is planned to be used for food purposes.

Slaughter for cattle meat is allowed no earlier than 49 days, pigs - no earlier than 33 days after administration of the drug.

Storage

The shelf life of the drug in the manufacturer's closed packaging, subject to storage conditions, is 2 years from the date of production, after the first opening of the bottle – 30 days.

The drug is stored in the manufacturer's closed packaging, in a place protected from moisture and direct sunlight, at a temperature from 2 ° C to 26 ° C.


The information provided in this catalog is for reference only. There may be some changes in the characteristics, packaging and packaging of products.

AVZ reserves the right to make such changes without notice. You can get full information about the updated products from your personal manager or your nearest AVZ dealer.

All drugs for veterinary use from this catalog may be contraindicated and when using it is necessary to familiarize yourself with the Instructions for Use.

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