Alezan paste for oral use

Product benefits:

•  High efficiency.
•  Convenient presentation.
•  Excretes all types of parasites.

Chemical composition and pharmacological properties

Alezan paste for oral use contains praziquantel - 10% and ivermectin - 2% (as active ingredients), as well as excipients.

It is a combined antiparasitic drug. It provides significant nematodocidic and cestodocidic effect on all development phases of roundworms (including Delafondia vulgaris, Alfortia edentatus, Dictyocaulus amfieldi, Parascaris equorum, Strongylus equinus, Strongyloides westeri, Setaria equine), and cestodes (such as Anoplocephala magna, Anoplocephala perfoliata and Paranoplocephala mamillana), as well as larvicidal action on larvas of horse botflies (Gastrophilus spp.) parasitizing horses.

Praziquantel (a component of the drug) is a pyrazine isoquinoline compound. The mechanism of action includes increase in cellular membrane permeability for calcium ions in roundworms and cestodes causing general muscular clonus and constant paralysis which lead to death of worms.

Ivermectin is a macrocyclic lactone with broad-spectrum antiparasitic action including roundworms and botfly larvas. Mechanism of ivermectin action involves influence on chloride ion current level through membranes of nervous and muscle cells of a parasite. Primary targets are glutamate-gated chloride channels and GABA receptors. Change in chloride ion current level damages neural impulse conduction resulting in paralysis and death of parasites.

Indications

Use Alezan paste for oral use to deworm horses with nematodosis (including delafondiosis, alfortiosis, trichonematosis, parascaridosis, oxyuriasis, strongylosis, strongyloidosis, parafilariosis, setariosis, habronemiasis and drascheiosis), cestodiasis (anoplocephalidose) and associative invasions (poly invasions) caused by roundworms, cestodes and botfly larvas.

Contraindications

Increased individual sensitivity to the drug components. Do not use in milking mares with esculent milk, animals <100 kg, as well as in debilitated, contagious and recovering animals.

Adverse events

Adverse events and complications are not observed in case of administration as per package insert.

Dosage and administration

Single oral administration (1 g per 100 kg of body weight). Press out paste from a syringe dispenser on the base of tongue. Insert device in interdental space of oral cavity, then lift animal head within several seconds. Fix volume of paste per a horse by moving a fixator on plunger rod and appropriate dose fixing. Each syringe division stands for 1 g of paste.
Treatment and prevention: 2-4 times in a year, depending on type of disease and environmental invasion degree (under ovo- and larvoscopic control) according to recommendations listed in the table.

Indications	Processing terms
strongyloidosis, delafondiosis, alfortiosis, strongylosis	At least once in 2 months during pasture season
trichonematosis	Twice (in spring and autumn) during pasture season
parascaridosis, oxyuriasis	Once in 2 months during housing season
habronemiasis, drascheiosis	In spring, summer and autumn (according to indications)
parafilariosis, setariosis, onchocercosis	Monthly during insect flight season (troubled farm units)
anoplocephalidose	In spring, summer and autumn (according to indications)
gastrophilosis	September-November (according to indications)

Before mass processings test each drug batch on small group (5-7 animals). In default of complications within 3 days, process all the livestock.

Special warnings

Animals are allowed to be slaughtered for meat not earlier than 20 days after deworming. Meat of compulsorily slaughtered animals received before stated period termination can be used to feed carnivorous animals.

Storage

Protect from light and moisture. Keep out of the reach of children and animals. Store separately from food and animal feeding at 0-20°С.

Pharmaceutical form

6.0 g syringe dispenser. Outer package - carton.