Thiamulin 80%

Product benefits:

• A wide range of antibacterial and antimycoplasmic effects
• Action on bacteria with intracellular localization in the body
  
• It is thermally stable in the composition of feed, the production technology of which includes heat treatment
  

Chemical composition and pharmacological properties

Thiamulin 80% contains in 1 g, as the active ingredient of thiamulin, hydrogen fumarate - 800 mg, respectively, and lactose and hydroxypropylmethylcellulose as excipients.

  Thiamulin hydrogen fumarate, which is part of the drug, is a semi-synthetic antibiotic of the pleuromutin group and has a wide spectrum of action against mycoplasmas, including Mycoplasma hyopneumoniae, M hyorhinis, M hyosynoviae, M synoviae, M gallisepticum, M meleagridis; gram-positive and some gram-negative bacteria, including Actinobacillus spp., Bacteroides spp., Campylobacter spp., Clostridium spp., Corynebacterium spp., E. coli, Enterococcus cecorum, Erysipelothrix spp., Fusobacterium spp., Haemophilus spp., Klebsiella pneumoniae, Leptospira spp., Listeria spp., Pasteurella spp., Staphylococcus spp., Streptococcus spp., Treponema hyodesenteriae, Lawsonia intracellularis, and brachispira (Vgashuspiga hyodysenteriae, Brachyspira innocens, Brachyspira. pilosicoli, Brachyspira suis); does not act on microorganisms of the Enterobacteriaceae family (Salmonella spp. and Escherichia coli).
The mechanism of bacteriostatic action of thiamulin is a violation of microbial cell protein synthesis (including intracellular localization in the body) at the ribosomal level, which leads to suppression of the growth and development of microorganisms.

After oral administration of the drug, thiamulin is rapidly absorbed in the gastrointestinal tract of animals and penetrates into many organs and tissues, where it reaches maximum concentrations in 0.9-1.0 hours after administration. Thiamulin is metabolized to inactive metabolites and is excreted from the body mainly with feces and urine.

Indications

Thiamulin 80% is prescribed for therapeutic and prophylactic purposes to pigs with gastrointestinal and respiratory diseases of bacterial etiology, including dysentery, enzootic pneumonia, pleuropneumonia, proliferative enteropathy (ileitis), colitis and other infections whose pathogens are sensitive to thiamulin.

Contraindications

A contraindication to the use of the drug Tiamulin 80% is an increased individual sensitivity to the components of the drug. The drug should not be used in pigs with severe impaired liver and kidney function. 

The possibility of using the drug Tiamulin 80% to pregnant and lactating sows is determined by the attending veterinarian if the expected benefit of using the drug exceeds the potential harm to the fetus.

Dosage and administration

Thiamulin 80% is used in a mixture with feed, individually or in a group way. Thiamulin 80% is mixed with the daily norm of feed consumed by pigs. Thiamulin is 80% thermally stable, which makes it possible to introduce the drug into the composition of feed, the production technology of which includes heat treatment.

Thiamulin is 80% thermally stable, which makes it possible to introduce the drug into the composition of feed, the production technology of which includes heat treatment.


The doses and frequency of use of the drug for pigs are indicated in the table

Indications for use	Daily dose of the drug, g / 100 kg of weight
		Course of application
Dysentery caused by B. hyodysenteriae	1,1 g	3-5 days
Enteropathy (ileitis) caused by Lawsonia intracellularis and colitis caused by B.pilosicoli		5 days
Enzootic pneumonia caused by M. hyopneumoniae, including complicated by R. multocida and A. pleuropneumoniae	1,9-2,5 g	5-10 days
Pleuropneumonia caused by A. pleuropneumoniae	2,5 g	5-7 days

During the treatment period, animals should receive only water or food containing the drug.

It is allowed to use the drug in a therapeutic dose to a group of animals in contact with sick animals, but without clinical signs of the disease, if such animals are kept in a group way with sick animals or if the same equipment is used to care for such animals.

Adverse events

When using Thiamulin 80% in accordance with this instruction, side effects and complications are usually not observed. In case of allergic reactions, the use of Thiamulin 80% is discontinued and antihistamine medications and symptomatic therapy are prescribed.

Simultaneous or sequential use of Thiamulin 80% with monenzine, salinomycin, narazine and other ionophoric coccidiostatics, aminoglycoside antibiotics, as well as for 7 days before and 7 days after the use of these drugs is not allowed, due to the possible occurrence of complications and side effects in animals (diarrhea, anorexia, paresis, nephrotic effects).

Special warnings

Slaughter for turkey meat is allowed no earlier than 4 days, broilers - no earlier than 3 days, pigs - no earlier than 4 days after the last use of the drug. The meat of poultry and pigs, forcibly killed before the expiration of these terms, can be used to feed fur-bearing animals.

Storage

The drug is stored in the manufacturer's closed packaging, in a place protected from moisture and direct sunlight, at a temperature from 2 ° C to 25 ° C.