Monizen® Forte solution for injection

Product benefits:

• Highly active against adult and larval phases of parasite development
•  It works with nematodes, cestodoses, trematodes and arachno-entomoses
•  Provides long-term prevention of parasitosis

Chemical composition and pharmacological properties

Monizen® Forte contains in 1 ml ivermectin – 5 mg and praziquantel – 60 mg as active ingredients, and as auxiliary substances: benzyl alcohol, methylpyrrolidone and propylene glycol.

In appearance, the drug is a transparent liquid from colorless to pink in color.

Monizen® Forte belongs to the group of combined antiparasitic drugs.

Praziquantel and ivermectin, which are part of Monizen® Forte, provide a wide range of antiparasitic effects of the drug. MONIZENforte is active against the imaginal and larval phases of the development of nematodes of the gastrointestinal tract and lungs, cestodes, trematodes, larvae of gadflies, sarcoptoid, gamazoid and ixod mites, bloodsuckers, malophages (hair eaters, fluff eaters, peroeds) of mammals and birds.

Ivermectin is a synthetic derivative of avermectin, the producer of which is the actinomycete Streptomyces avermitilis, belongs to the group of macrocyclic lactones. The mechanism of action of ivermectin is its effect on the penetration of chlorine ions through the membranes of nerve and muscle cells of ecto- and endoparasites. The main target is glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the process of penetration of chlorine ions disrupts the conduction of impulses, which leads to paralysis and death of the parasite.

Praziquantel is a synthetic derivative of pyrazinisoquinoline. The mechanism of action of praziquantel is based on depolarization of neuromuscular ganglioblockers, impaired glucose transport and microtubular function of cestodes, which causes a violation of muscle innervation, paralysis and death of helminths.

After parenteral and oral administration of the drug, praziquantel and ivermectin are well absorbed, enter the systemic circulation and are distributed in organs and tissues of animals and farm birds, providing a long-term antiparasitic effect.

Indications

Monizen® Forte is used for prophylactic and therapeutic purposes for large and small cattle, deer and agricultural birds with cestodoses, nematodes of the lungs and gastrointestinal tract, trematodes, estrosis, psoroptosis, chorioptosis, sarcoptosis, ixodidosis, siphunculatosis, melophagosis, bovicoles, hypodermatosis.

Contraindications

Contraindication to use is an individual hypersensitivity of the animal to the components of the drug, including in the anamnesis. It is not allowed to use Monizen® Forte to emaciated, sick with infectious diseases and recovering animals, dairy and pregnant animals less than 28 days before delivery, due to the release of the drug with milk.

Dosage and administration

Monizen® Forte solution for injection is used intramuscularly for cattle and deer, subcutaneously for small cattle individually once for helminthiasis and gadfly infestations and twice with an interval of 10-14 days for other arachno-entomoses.

If the volume of the injected solution is more than 10 ml, it should be administered to the animal in several places.

Monizen® Forte solution for injection is prescribed in the following doses:

Type of animal	Method of administration, dose of MONIZEN® forte ml / kg of animal weight
Cattle, deer	Intramuscularly With nematodoses – 1 ml / 20 kg With trematodoses – 1ml / 15 kg With cestodoses – 1 ml / 20 kg For arachno-entomoses – 1 ml / 20 kg
Sheep	Subcutaneously, orally With nematodoses – 1 ml / 20 kg With trematodoses – 1ml / 15 kg With cestodoses – 1 ml / 20 kg For arachno-entomoses – 1 ml / 20 kg
Goats	Subcutaneously, orally With nematodoses – 1 ml / 15kg With trematodoses – 1ml / 15 kg With cestodoses – 1 ml / 15 kg For arachno-entomoses – 1 ml / 20 kg

– cattle, sheep, deer with nematodoses of the gastrointestinal tract (hemonchosis, bunostomosis, esophagostomosis, nematodirosis, habertiosis, cooperiosis, ostertagiosis, strongyloidosis, trichostrongylosis, trichocephalosis, neoascariasis) – 1 ml per 20 kg of animal weight;
– large and small cattle, deer with lung nematodoses (dictyocaulosis, mulleriosis, cystocaulosis, protostrongilidosis) and cestodoses (moniesiosis, avitellinosis, tizanesiosis) – 1 ml per 20 kg of animal weight;

– cattle, deer, sheep with trematodoses (fasciolosis, dicroceliosis) – 1 ml per 15 kg of animal weight;

– goats with nematodoses (hemonchosis, bunostomosis, esophagostomosis, nematodirosis, habertiosis, cooperiosis, ostertagiosis, strongyloidosis, trichostrongylosis, trichocephalosis, neoascariasis), cestodoses (moniesiosis, avitellinosis), trematodoses (fasciolosis, dicroceliosis) – 1 ml per 15 kg of animal weight;

– sheep with estrosis once, individually subcutaneously – 1 ml per 20 kg of animal weight;

– cattle with hypodermatosis once, individually intramuscularly – 1 ml per 20 kg of animal weight

– cattle, small cattle, deer with psoroptosis, sarcoptosis, chorioptosis, melophagosis, bovicolese are treated twice (2 times) with an interval of 10-14 days, with ixodidosis – once, at a dose of 1 ml per 20 kg of animal weight;

Adverse events

When using Monizen® Forte in accordance with this instruction, side effects and complications are usually not observed. With increased sensitivity of the animal to the components of the drug and the appearance of allergic reactions, the use of the drug is discontinued and antihistamines and symptomatic therapy are prescribed.

Special warnings

Slaughter for meat of cattle, small cattle and deer is allowed no earlier than 35 days, geese and ducks no earlier than 20 days, chickens and turkeys no earlier than 15 days after the last application of Monizen® Forte. In case of forced slaughter of animals and farm birds before the deadline, the meat can be used as fodder for fur-bearing animals.

Storage

The drug is stored in the manufacturer's closed packaging, in a place protected from direct sunlight, separately from food and feed at a temperature from 2 ° C to 30 ° C.