Iversan oral use

Product benefits:

•  Antiparasitic drug which is active not only against worms, but insects and ticks parasitizing animals.
•  Monodrug for combined therapy.
•  Convenient method of administration.

Chemical composition and pharmacological properties

100 ml of Iversan contain ivermectin - 4 mg (as an active ingredient) and excipients.
Iversan is a macrocyclic lactone antiparasitic drug.
Ivermectin (a component of the drug) is active against larval and mature development phases of gastrointestinal and pulmonary roundworms, fleas, sucking lice, lice, biting lice, louse flies, sarcoptic and mole ticks parasitizing pigs, poultry, fur animals and dogs.
Mechanism of ivermectin action involves influence on chloride ions current level through membranes of nervous and muscle cells of a parasite. Primary targets are glutamate-gated chloride channels and GABA receptors. Change in chloride ions current level damages neural impulse conduction resulting in paralysis and death of parasites. Ivermectin well absorbs in gastrointestinal tract with further penetration in organs and tissues obtaining peak blood concentration in 4-6 hours (pigs and carnivorous animals) or 1 hour (poultry) after oral administration. This active ingredient is mainly excreted unchanged in feces and partially in urine. Also it is excreted in milk of lactating animals.

Indications

Use Iversan to treat and prevent nematodosis and arachnoentomosis in pigs, poultry (hens, geese, ducks and turkeys), dogs and fur animals.

Contraindications

Individual increased sensitivity to Iversan components and other drugs containing avermectins. Do not use in contagious and debilitated animals, pregnant females, as well as in dogs and fur animals under 2 months old. Do not use in laying hens, henny replacements (less than 14 days before egg-laying starts) due to ivermectin accumulation in eggs.
Iversan administration in Collies, Bobtails and Shetland sheepdogs must be performed under attending veterinarian's control due to increased sensitivity of these breeds to macrocyclic lactones.
Do not use in combination with other drugs containing macrocyclic lactones.

Administration

Iversan administration:
• pigs - group use with drinking water, daily dose is 1 ml per 100 kg of body weight
(400 µg of ivermectin per 1 kg of body weight);
• dogs and fur animals - individual use with small amount of feed or drinking water, single dose is 0.05 ml per 10 kg of body weight (200 µg of ivermectin per 1 kg of body weight);
• poultry - group use with drinking water, daily dose is 10 ml per 100 l of water.
Drug administration schedule which depends on type of parasitic disease is listed in the following table:

Type of animal	Disease	Drug administration schedule
Poultry (hens, geese, ducks, turkeys) and pigs	nematodosis	single dose
	arachnoentomosis	twice, 14 days apart.
Dogs, fur animals	nematodosis	once
	otoacariasis, notoedrosis, sarcoptic mange, demodicosis	once in 3 days within 21 days
	aphanipterosis, linognathosis, trichodectosis, cheyletiellosis	twice, 14 days apart

Group administration: in order to prepare Iversan medical solution, dissolve a dose aimed at treated livestock in ¼ or ¹/₃ of water day's allowance consumed by poultry or pigs, respectively. Prepare this medical solution every day.

Adverse events

Adverse events and complications are not generally observed in case of administration as per this package insert. Stop drug administration in case of increased individual sensitivity to the drug components and allergic reactions. Perform desensitizing therapy.

Drug is toxic for bees, fish and other aquatic organisms.

Waiting period

Pigs and poultry are allowed to be slaughtered for meat not earlier than 21 and 9 days, respectively, after the last Iversan administration. Meat of compulsorily slaughtered animals received before stated period termination can be used to feed fur animals.

Storage

Store in closed original package. Protect from direct sunlight and moisture. Keep out of the reach of children and animals. Store separately from food and animal feeding at 5-25°С.

Shelf life is 2 years from manufacturing date when stored in closed original package in accordance with regulations and 42 days after the first unpacking.

Pharmaceutical form

The drug is manufactured in 100 and 1000 ml polymeric bottles.