Florfenicol 40% injection

Product benefits:

• Effective in respiratory diseases caused by bacteria and mycoplasma.

• Low level of resistance of microorganisms.

• A single SC dosing.

Chemical composition and pharmacological properties

1 ml of Florfenicol 40% contains florfenicol - 400 mg as an active ingredient; as well as benzyl alcohol, methylpyrrolidone as excipients.

Appearance: transparent colorless to greenish-yellow liquid.

Florfenicol 40% belongs to the amphenicols pharmacotherapeutic group. Florfenicol is a derivative of thiamphenicol, in the molecule of which the hydroxyl group is replaced by a fluorine atom, has a bacteriostatic effect against Actinobacillus pleuropneumoniae, Pasteurelia spp., Salmonella choleraesuis, Bordetella bronchiseptica, Haemophilus spp., Staphylococcus s pp., Streptococcus spp., Klebciella pneumoniae, Moraxella bovis, including bacteria that produce acetyltransferase and are resistant to chloramphenicol as well as mycoplasmas M. hyopneumoniae and M. hyorhinis.

After binding to the 50S ribosomal subunit in the protoplasm of a bacterial cell, it blocks the enzyme peptidyltransferase, which leads to inhibition of protein synthesis in sensitive microorganisms at the ribosomal level.

After parenteral administration, florfenicol is rapidly absorbed from the injection site and is distributed into most organs and tissues. Bacteriostatic blood concentrations of florfenicol after a single intramuscular injection persist for at least 48 hours, and at least 100 hours after subcutaneous administration.

Antibiotic is excreted in unchanged form and in the form of metabolites mainly with urine, and, to a lesser extent, with feces.

According to the extent of exposure, Florfenicol 40% belongs to the group of moderately hazardous substances (hazard class 3 according to GOST 12.1.007).

Indications

Florfenicol 40% is used in pigs and cattle for the treatment of respiratory infections, including pleuropneumonia caused by Actinobacillus pleuropneumoniae, Haemophilus pa rasu is, Pasteure Ila múltoddá, M. hyopneumoniae, M. hyorhinis, Klebciella pneumoniae, Streptococcus pneumoniae, Haemophilus somnus, atrophic rhinitis, and other primary and secondary bacterial diseases, caused by sensitive pathogens.

Contraindications

Florfenicol 40% is contraindicated in case of an individual hypersensitivity of the animal to florfenicol. Florfenicol 40% should not be used in boars and bulls-producers, as well as dairy cows whose milk is used for food purposes.

Dosage and administration

Florfenicol 40% is used:

– cattle – at a dose of 1 ml per 20 kg of animal weight intramuscularly twice with an interval of 48 hours, or at a dose of 2 ml per 20 kg of animal weight subcutaneously once;

– pigs – at a dose of 1 ml per 30 kg of animal weight intramuscularly twice with an interval of 48 hours.

The maximum volume for the administration of the drug in one place should not exceed 20 ml for cattle, 5-10 ml for small animals. If the volume of the injected drug is more than specified, it should be administered to animals in several places.

Due to a possible pain reaction, the maximum volume of the drug for administration in one place should not exceed 10 ml.

Adverse events

When using Florfenicol 40% in accordance with this instruction, side effects and complications are usually not observed. In rare cases, piglets may have redness, swelling of the perianal area and soft feces, which are short-term, spontaneously pass and do not require the use of medications. In some animals, a local reaction in the form of edema may occur at the injection site. With increased individual sensitivity of the animal to the components of the drug and the appearance of allergic reactions, the use of the drug is discontinued and symptomatic treatment is carried out.

Special warnings

Simultaneous use of Florfenicol 40% with thiamphenicol, penicillin group antibiotics, cephalosporins and fluoroquinolones is not allowed, as well as its mixing in one syringe with other medications.

Slaughter for pig meat is allowed no earlier than 16 days; cattle – no earlier than 36 days after repeated intramuscular administration of the drug and 50 days after subcutaneous administration.

Storage

The shelf life of the drug in the manufacturer's closed packaging, subject to storage conditions, is 3 years from the date of production, after the first opening of the bottle – 30 days. The drug is stored in the manufacturer's closed packaging, in a place protected from direct sunlight, at a temperature from 2 ° C to 25 ° C.