Aquaphlox AVZ oral solution

Benefits:

• The combination of levofloxacin and colistin sulfate provides a broad-spectrum of antimicrobial activity of the drug against:

• AEROBIC GRAM-NEGATIVE organisms (Escherichia coli, Salmonella spp., Haemophilus spp, etc.),

•  AEROBIC GRAM-POSITIVE organisms (Arcanobacterium spp., Bacillus spp., Corynebacterium spp., Enterococcus spp., Listeria spp., Staphylococcus spp., etc.),

•  ANAEROBIC ORGANISMS (Clostridium perfringens, Clostridium spp., Bacteroides fragilis, Bacteroides spp., Fusobacterium spp., Peptostreptococcus spp.),

• MYCOPLASMA, CHLAMYDIA, MYCOBACTERIA AND RICKETTSIA

Composition and pharmacological properties.

1 ml of Aquaphlox AVZ oral solution contains levofloxacin (hemihydrate) - 150 mg and colistin sulfate - 2 mln IU as active ingredients. And hydrochloric acid and purified water as excipients.

Levofloxacin, which is a component of the drug, is a synthetic antibiotic from the group of fluoroquinolones. The mechanism of action of levofloxacin is based on the block of DNA gyrase (topoisomerase II) and topoisomerase IV, affecting superspiralization and crosslinking of deoxyribonucleic acid breaks, inhibition of deoxyribonucleic acid synthesis, deep metabolic changes in the cytoplasm, cell wall and membranes.

Levofloxacin is rapidly and almost completely absorbed after oral administration. The intake of feed has little effect on the rate and completeness of absorption. The bioavailability of levofloxacin after oral administration is 99%, time to maximum serum concentration is 2 hours post-dose, and the half-life is about 7 hours. Levofloxacin penetrates into organs and tissues, including: lungs, bronchial mucosa, sputum, genitourinary organs, polymorphonuclear leukocytes, alveolar macrophages. After oral administration, it is excreted mainly in urine unchanged within 48 hours and, and in small amount with feces within 72 hours. In liver and kidney dysfunction, elimination period may increase.

Colistin sulfate is a compound of the polymyxin group of polypeptide antibiotics. The mechanism of bactericidal action of colistin is based on its binding with bacterial lipoproteins and violation of the permeability of the cell wall, which leads to the loss of amino acids, inorganic ions, purines, pyrimidines by the bacterial cell and causes its death.

After oral administration colistin sulfate is virtually not absorbed in the gastrointestinal tract and is not exposed to digestive enzymes, as a result, a high concentration of the antibiotic is reached in the intestines; it does not accumulate in organs and tissues, and is excreted mainly unchanged with feces.

Indications

Aquaphlox AVZ oral solution is prescribed to poultry and ornamental pigeons for treatment and prevention of colibacteriosis, salmonellosis, pasteurellosis, pseudomoniasis, mycoplasmosis, hemophilosis, streptococcosis, necrotic enteritis, to pigs in bacterial diseases of the respiratory system, gastrointestinal tract, genitourinary system, skin and soft tissue infections caused by levofloxacin- and colistin-sensitive pathogens, as well as mycoplasma infections.

Contraindications.

Individual hypersensitivity of animals to the components of the drug, liver and/or kidney failure, cartilage tissue development disorders, nervous system lesions, accompanied by seizures. Do not administer the product to laying hens and repair young chickens less than 10 days before the start of egg laying, due to the accumulation of levofloxacin in eggs.

Side effects.

When the drug is used in accordance with instructions, side effects and complications have not been established. In case of allergic reaction, discontinue treatment and start symptomatic and desensitizing therapy.

In case of an overdose, anxiety, disorientation, loss of appetite, nausea, diarrhea, sometimes tendon lesions (including tendinitis), joint and muscle pain are observed. In these cases, discontinue treatment with the drug. There are no specific antidote. General measures are taken to eliminate the drug from the body, and symptomatic treatment is carried out.

Posology and method of administration

Aquaphlox AVZ oral solution is administered individually or in groups with drinking water over 3-5 days at the following doses:

- broiler chickens, rearing flocks and parent flock (chicken), decorative pigeons - 0.35 ml of the drug per 1 liter of drinking water;

- turkeys - 0.5 ml per 1 liter of drinking water (0.5 ml of the drug per 10 kg of bodyweight);

- pigs – 0.35 ml of the drug per 10 kg of animal bodyweight.

In salmonellosis, severe colibacteriosis, mixed infections, as well as in chronic forms of diseases, the dose of the drug is doubled, treatment course is at least 5 days.

To prevent the spread of diseases, the drug can be prescribed at therapeutic dose to a group of animals in contact with a sick animal who has no clinical signs of the disease.

During treatment period, animals and poultry should consume only water containing the drug. The therapeutic solution is prepared daily based on the daily water requirements of animals and poultry.

Special warnings.

Aquaphlox AVZ oral solution is not intended for use in sows during pregnancy and breastfeeding of offspring, as well as newborn piglets, due to the lack of data on the study of the effect on the body.

Storage.

Store the product in a closed manufacturer's package, protected from direct sunlight at 2°C to 25°C. The shelf life of the product, when stored at the specified conditions in a closed manufacturer's package, is 2 years since the date of manufacture, after opening of the primary package - 30 days. Do not use after the expiry date.

Dosage form.

The drug is packaged in 10 and 100 ml polymer bottles, 1 l polymer bottles, 5 l polymer cans