Amoxiyantar

Product benefits:

• A drug with antimicrobial and antioxidant action for rapid recovery and recovery of the animal     
  
• Increases the sensitivity of microorganisms to therapy by increasing the permeability of bacterial cell membranes
  
• Stimulates the destruction of bacterial biofilms in the body of animals
  

Chemical composition and pharmacological properties

   1 g of Amoxiyantar contains amoxicillin (trihydrate) - 574 mg and succinic acid (5 mg) as active ingredients, and excipients: sodium carbonate, lactose, aerosil.

Appearance: white to light-yellow powder.

Amoxiyantar belongs to the pharmacotherapeutic group of penicillins in combinations.

Amoxicillin (trihydrate), which is a component of the drug, has a broad-spectrum bactericidal effect against gram-positive and gram-negative microorganisms, including: Acinetobacter spp., Actinobacillus spp., Bordetella bronchiseptica, Clostridium perfringens; Clostridium spp., Coreynebacterium spp., E. coli, Haemophilus parasuis, Haemophilus spp., Klebsiella pneumonia, Moraxella spp., Pasteurella spp., Proteus spp., Pseudomonas aeruginosa, Salmonella spp., Staphylococcus spp., Streptococcus spp.

The mechanism of action of amoxicillin is associated with the inhibition of the functional activity of bacterial enzymes (penicillin-binding proteins) that play a key role in the biosynthesis of peptidoglycan. Peptidoglycan is a structural element of the bacterial cell wall. Inhibition of peptidoglycan synthesis causes degradation of the cell wall, which is usually followed by lysis and death of the bacterial cell.

Amoxicillin is a first-choice drug for symptomatic treatment based on a preliminary diagnosis.

Succinic acid is an endogenous intracellular metabolite in the Krebs cycle. It reduces the production of free radicals, normalizes gas composition of the blood, has metabolic, antioxidant, and antihypoxic effects. Restores the energy potential of the cell and enhances the process of neutralization of various toxic substances.

Succinic acid, as a component of the drug, increases the sensitivity of microorganisms to amoxicillin by increasing the permeability of the bacterial cell membrane, thereby extending the contact area of the drug with gram-positive and gram-negative organisms.

After oral administration, amoxicillin is rapidly absorbed in the gastrointestinal tract of animals and penetrates into many organs and tissues, reaching maximum concentrations in 0.7-1.5 hours after administration.

Succinic acid is metabolized to a background level within 1 hour.

Amoxicillin is excreted with urine and feces mainly in unchanged form.

According to the extent of exposure after oral administration, Amoxiyantar refers to the low-risk products (hazard class 4 according to GOST 12.1.007-76).

Indications

Amoxiyantar is indicated in following conditions:

– Pigs: for the treatment of respiratory, gastrointestinal and mixed bacterial infections caused by Actinobacillus pleuropneumoniae, E. coli, Haemophilus parasuis, Pseudomonas aeruginosa, Pasteurella spp., Bordetella bronchiseptica, Staphylococcus aureus, as well as other primary and secondary bacterial diseases, caused by pathogens sensitive to amoxicillin.

– Broiler chickens and rearing flocks for the treatment of coli-bacteriosis, salmonellosis, staphylococcosis, as well as other primary and secondary bacterial infections, caused by pathogens sensitive to amoxicillin.

Contraindications

Amoxiyantar is contraindicated in animals with individual hypersensitivity to beta-lactam antibiotics, as well as in severe liver and kidney injury. Amoxiyantar should not be used in rearing flocks 2 weeks before the start of egg laying, as well as in laying hens whose eggs are intended for human food, as amoxicillin excreted with eggs.

Dosage and administration

   Amoxiyantar is administered individually or in groups in pigs orally with drinking water or as a mixture with feed, in poultry orally with drinking water.

Doses of Amoxiyantar are shown in the table.

Type of animal	The dose of the drug
Pigs	1.75-3.5 g/100 kg of livestock weight. The course of treatment is 3-5 days.
Broiler chickens, repair young chickens

Before use, normal daily water consumption is calculated and a working solution is prepared in the required concentration.

The required amount of Amoxiyantar per 1 liter of water is calculated according to the formula

m =	3.5 x M of the flock	, where
	V of water

m - amount of Amoxiyantar (g/l);

3.5 - daily dose of Amoxiyantar (g/100 kg);

M - total weight of the treated livestock (kg);

V - total daily water consumption by livestock (l).

During the treatment period, animals should receive only water or food containing the drug.

It is allowed to use the drug in a therapeutic dose in a group of animals that were in contact with sick animals, but who do not show clinical signs of the disease, if such animals are kept in a group with sick animals or if the same equipment is used to care for such animals.

Side effects

When Amoxiyantar is used in accordance with these instructions, the risk of side effects and complications is low. In case of allergic reactions, Amoxiyantar is discontinued and antihistamines and symptomatic therapy are prescribed.

Special warnings

It is prohibited to use Amoxiyantar simultaneously with bacteriostatic antibiotics (tetracycline group, macrolides) due to a risk of reduced activity (antagonistic effect).

Slaughter of pigs and poultry is allowed not earlier than after 6 and 4 days after the last use of the drug, respectively. The meat of animals forcibly slaughtered before the expiration of the specified period can be used to feed fur-bearing animals.

Storage

Amoxiyantar is stored in a closed original packaging, in a place protected from moisture and direct sunlight, at 2 °C to 25 °C.

The shelf life of the drug stored in accordance with instructions in a closed manufacturer's packaging is 3 years from the date of manufacture, in an opened package - 3 months. Do not use after the expiry date.