FLORFENICOL GRANULES

Benefits

• It is active against strains resistant to penicillin, streptomycin, sulfonamides
• Heat-resistant granulate
• Time to maximum blood concentration is 1 hour, therapeutic effect persists for up to 24 hours post-dose

Composition and pharmacological properties.

Florfenicol granules contain 40 mg of florfenicol per 1 g as active ingredient as well as RUSNUT bulking agent and paraffin oil as excipients. Appearance: light brown to brown granules with dark and light inclusions.
Florfenicol granules belongs to the amphenicols pharmacotherapeutic group. Florfenicol is a derivative of thiamphenicol, in the molecule of which the hydroxyl group is replaced by a fluorine atom, has a bacteriostatic effect against Actinobacillus pleuropneumoniae, Pasteurelia spp., Salmonella choleraesuis, Bordetella bronchiseptica, Haemophilus spp., Staphylococcus s pp., Streptococcus spp. , Klebciella pneumoniae, Moraxella bovis, including bacteria that produce acetyltransferase and are resistant to chloramphenicol as well as mycoplasmas M. hyopneumoniae and M. hyorhinis.
After binding to the 50S ribosomal subunit in the protoplasm of a bacterial cell, it blocks the enzyme peptidyl transferase, which leads to inhibition of protein synthesis in sensitive microorganisms at the ribosomal level. After oral administration, florfenicol is readily and rapidly absorbed from the intestinal tract and penetrates into all organs and tissues. The bioavailability of the drug is 88%. Time to maximum blood concentration of the antibiotic is 1 hour after oral administration, the antibacterial concentration in the organs and tissues of the animal persists for 24 hours. Florfenicol is excreted from the body mainly with urine and to a lesser extent with feces: 50% unchanged and 50% in the form of metabolites, the main of which is florfenicol amine. According to the extent of exposure, Florfenicol granules belongs to the low-risk products (hazard class 4 according to GOST 12.1.007).

Indications

Florfenicol granules are used in pigs for treatment of respiratory infections, including pleuropneumonia caused by Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Pasteurella multocida, Klebsiella pneumoniae, Streptococcus pneumoniae, Haemophilus somnus, atrophic rhinitis, as well as other primary and secondary bacterial diseases whose pathogens are sensitive to florfenicol.

Contraindications.

Florfenicol granules are contraindicated in case of an individual hypersensitivity of the animal to florfenicol.
Do not administer Florfenicol granules in boars, pregnant and milking sows.
Do not co-administer Florfenicol granules with thiamphenicol, penicillin antibiotics, cephalosporins and fluoroquinolones.

How to use.

Florfenicol granules are administered in pigs mixed with feed at a daily dose of 5-10 mg of florfenicol per 1 kg of animal bodyweight (which is equivalent to 125-250 mg of the drug per 1 kg of animal bodyweight or 2.5-5 kg of the drug per 1 ton of feed) for 5-7 days.
Florfenicol granules are thermally stable, which makes it possible to introduce the drug into the composition of feeds, produced with the use of short-term heat treatment technology.
Symptoms of overdose may manifest as disorders of the gastrointestinal tract, a decrease in animal consumption of feed and water, and as a result, reduced weight gain.

Side effects.

When Florfenicol granules is used in accordance with this instructions, the risk of side effects and complications is low. In rare cases, redness, swelling of the perianal area and soft feces are possible in piglets. These effects are short-term, resolve spontaneously and do not require drug therapy. 
In case of individual hypersensitivity to the components of the drug and in allergic reactions, the drug is discontinued and symptomatic treatment is carried out.

Special warnings.

Strictly follow the recommended interval, as non-compliance may lead to a reduced therapeutic effect. If repeated dose is missed, administer the product as soon as possible at the prescribed dose.
Slaughter of pigs for meat is allowed not less than 14 days after the last dose. The meat of animals forcibly slaughtered before the expiration of the specified period can be used to feed fur-bearing animals.

Storage.

Store in a closed original packaging, in a place protected from moisture and direct sunlight, at 2°C to 25°C. Keep out of reach of children.
Shelf life of the drug in the closed original package when stored in the appropriate conditions, is 3 years from the date of manufacture. In an opened primary package - 3 months. Do not use after the expiry date.

Dosage form.

1 kg and 10 kg polymer buckets, capped with tamper-evident polymer lids, 1 kg bags of combined materials, 25 kg bags of paper and combined materials.