DOXY AVZ 500

Product benefits:

• It is more rapidly absorbed, better tolerated and has a longer half-life vs. tetracycline.\

•  It is well distributed into most organs and tissues, also has an effect on intracellular microorganisms.ody

• It is freely soluble in water.

Chemical composition and pharmacological properties

1 g of DOXY AVZ 500 contains 500 mg of doxycycline as an active ingredient, and lactose and tartaric acid as excipients.

DOXY AVZ 500 belongs to the tetracyclines pharmacotherapeutic group.

Doxycycline in the composition of the drug is a semi-synthetic antibiotic of the tetracycline group. It is active against many gram-positive (Staphylococcus spp., Streptococcus spp., Actinomyces spp., Clostridium spp., Bacillus anthracis, Corynebacterium spp., Erysipelotrix spp., Listeria spp.) and gram-negative species (Haemophilus spp., Pasteurella spp., Bordetella spp., Bartonella spp., Actinobacillus pleuropnevmoniae, Escherichia coli, Salmonella spp., Campylobacter spp.), as well as mycoplasmas (M. synoviae, M.hyopneumoniae, M. hyorhinis, M.hyosynoviae), spirochaete, Chlamydia spp., Rickettsia spp.

The mechanism of bacteriostatic action of doxycycline is due to the inhibition of the activity of enzymes that catalyze the binding of aminoacetyl-RNA to ribosomal membrane acceptors thereby disrupting protein synthesis and inducing microbial cell death.

After oral administration, the antibiotic is well absorbed in the gastrointestinal tract and is distributed into most organs and tissues of the animal, time to maximum serum concentrations is 2 to 4 hours. Doxycycline is metabolized to a small extent, and is excreted from the body mainly with bile and urine.

According to the extent of exposure, DOXY AVZ 500 refers to low-hazardous substances (hazard class 4 according to GOST 12.1.007). It is well tolerated by animals when used in recommended doses and does not have embryotoxic and teratogenic properties.

Indications

DOXY AVZ 500 is used in pigs and poultry for treatment of bacterial respiratory and gastrointestinal diseases, including pasteurellosis, colibacillosis, salmonellosis, mycoplasmosis, bordetelliosis, dysentery and other diseases caused by pathogens sensitive to doxycycline.

Contraindications

 DOXY AVZ 500 is contraindicated in cases of individual hypersensitivity of the animal to the components of the drug. The drug should not be administered to laying hens and rearing flocks starting from the age of 16 weeks due to the accumulation of doxycycline in eggs, as well as in animals with severe renal and hepatic insufficiency.l.

Dosage and administration

Doxy AVZ 500 is used for the following indications:

•            pigs: with drinking water individually or in groups at a dose of 0.2 g of DOXY AVZ 500 per 10 kg of animal bodyweight (10 mg of doxycycline hyclate per 1 kg of animal bodyweight) daily for 3–5 days;

•            poultry: with drinking water individually or in groups at a dose of 0.4 g of DOXY AVZ 500 per 10 kg of animal bodyweight (20 mg of doxycycline hyclate per 1 kg of animal bodyweight) daily for 3–5 days. When DOXY AVZ 500 is administered with drinking water to poultry and pigs, the dose calculation is performed as follows:

mg of DOXY AVZ 500 per 1 kg bw x Total weight of the group in kg	= mg of DOXY AVZ 500 per 1 liter of water
Total amount of water consumed in liters

Solution for treatment is prepared daily. During the treatment period using group method of application, poultry and pigs should receive only water containing the drug

Side effects

When DOXY AVZ 500 is used in accordance with this instruction, the risk of side effects and complications is low. In animals and poultry with individual hypersensitivity to the components of the drug and with signs of allergic reactions, the drug is discontinued, and antihistamines and symptomatic therapy are prescribed..

Special warnings

Do not use DOXY AVZ 500 in parallel with bactericidal antibiotics, mineral supplements and medications containing calcium, magnesium, iron and aluminum salts (due to a possible reduction in absorption of the antibiotic).

Do not skip doses, as this may lead to a decrease in therapeutic effect. In case of skipping one or more doses, the administration of the drug should be resumed at the prescribed doses and in accordance with the corresponding regimen.

Slaughter of pigs and poultry for meat is allowed not earlier than 3 and 6 days after the last dose, respectively. The meat of animals, including poultry, forcibly slaughtered before the expiration of the specified period can be used to feed fur-bearing animals.

Storage

The drug is stored in a closed original packaging, in a place protected from moisture and direct sunlight, at 2 °C to 25 °C.

The shelf life of the drug in the original closed package when stored in compliance with the instructions is 3 years from the date of manufacture. In the opened package - not more than 3 months. Shelf-life of the prepared solution is 24 hours.