Ciprovet-pulmo powder for oral use

Product benefits:

•  Due to synergism of active substances, drug efficiency is significantly higher than in particular components.
•  Broad-spectrum antibacterial and mycoplasmal effect.
•  Rapidly absorbs in gastrointestinal tract.
•  Peak blood concentration is observed in 1-1.5 hours. Therapeutic concentration is maintained within 24 hours.
•  Combination of active ingredients prevents development of microorganism resistance to fluroquinolones.

Chemical composition and pharmacological properties

1 g of powder contains ciprofloxacin - 100 mg and tiamulin hydrogen fumarate - 450 mg as active ingredients.

Ciprovet-pulmo is a combined antibacterial drug.

Ciprofloxacin is a fluroquinolone antibiotic with broad-spectrum antibacterial and antimycoplasmal properties. It is active against gram-positive and gram-negative bacteria (including Echerichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp., Proteus spp., Yersinia spp., Haemophilus spp., Pseudomonas aeruginosa, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium spp., Corynebacterium diphtheriase, Staphylococcus aureus, Streptococcus spp. and Mycoplasma spp.).

Tiamulin hydrogen fumarate (a pleuromutilin antibiotic) provides bacteriostatic effect on mycoplasma (including М. hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. gallisepticum, M. synoviae, M. meleagridis), Spirochaeta (B. huodysenteriae, B. pilosicoli), gram-positive aerobes (including Staphylococcus spp., Streptococcus spp., Corynebacterium pyogenes) and anaerobes (Clostridiym perfringens), gram-negative anaerobes (including Lawsonia intracellularis, Bacteroides spp., Fusobacterium spp.) and aerobes (Actinobacillus pleuropneumoniae, Pasteurella multocida).

Ciprofloxacin obtains peak serum concentration in 1.5-2 hours. Therapeutic concentration remains within 24 hours.

Tiamulin hydrogen fumarate rapidly absorbs in gastrointestinal tract and penetrates in most of organs and tissues obtaining peak concentration in pigs and poultry in 3 hours. It remains at therapeutic level within 18-24 hours.

Indications

Use Ciprovet-pulmo to treat pigs or treat and prevent hens and turkeys with bacterial/mycoplasmal respiratory and gastrointestinal infections (including enzootic pneumonia, pleuropneumonia, salmonellosis, mycoplasmosis, colibacillosis) and others, agents of which are susceptible to ciprofloxacin and tiamulim.

Contraindications

Increased individual sensitivity to the drug components. Do not use in laying hens with esculent eggs, pregnant sows and animals with frank renal/hepatic impairment. It is not allowed to use in combination with monensin, salinomycin, narasin and other ionophoric coccidiostatic preparations (within 7 days before and after administration), as well as with aminoglycoside antibiotics, levomycetin, macrolides, tetracyclines, theophyllin and nonsteroidal anti-inflammatory drugs.

Administration

Oral individual or group administration with drinking water or feed. Treatment: pigs - 0.045 g per 1 kg of body weight. Daily dose consumption is provided by rearing of drug solution (400 g of powder per 1 ton of water). The course of use is 5-10 days.
  
Treatment and prevention: broiler chickens, replacements under 16 weeks old and parent livestock of hens and turkeys - 0.11 g per 1 kg of body weight. Daily dose consumption is provided by rearing of drug solution (550 g of powder per 1 ton of water). The course of use is 3-5 days.

Adverse events

Adverse events and complications are not generally observed in case of administration as per this package insert. In case of allergic reactions, stop drug administration. Use antihistaminic and symptomatic drugs.

Waiting period

Pigs and poultry are allowed to be slaughtered for meat not earlier than 14 and 12 days, respectively, after the last drug administration. Meat of compulsorily slaughtered animals received before stated period termination can be used to feed fur animals.

Storage

Store in closed original package. Protect from direct sunlight and moisture. Keep out of the reach of children and animals. Store separately from food and animal feeding at 5-25°С.

Pharmaceutical form

The drug is manufactured in 0.5 and 1.0 kg multilayer paper bags; 0.1, 0.2, 0.5 and 1.0 kg polymeric cans; 5.0 and 10 kg buckets; 5, 10, 15 and 20 kg multilayer paper sacks.