Ceftisyl suspension for injections
- Broad-spectrum antibacterial effect on most of agents of cattle bacterial infections.
- Rapidly penetrates in systemic blood and remains at therapeutic level for at least 7 days.
- Single use.
Chemical composition and pharmacological properties1 ml contains ceftiofur (ceftiofur crystalline free acid) - 200 mg (as an active ingredient) and excipients.
Ceftisyl is a third generation cephalosporin antibacterial drug.
Ceftiofur (a component of the drug) has broad-spectrum antibacterial effect on gram-positive and gram-negative bacteria (including Pasteurella spp., Haemophilus somnus, Escherichia coli, Salmonella spp., Staphylococcus spp., Streptococcus spp., Fusobacterium necrophorum, Arcanobacterium pyogenes, Porphyromonas levii). Mechanism of ceftiofur antibacterial action includes inhibition of functional activity of bacterial enzymes (transpeptidases) that participate in peptidoglycan binding (the main component of microorganism cellular wall) causing osmotic balance disorder and bacterial cell destruction. Peak blood concentration of ceftiofur and its metabolites is obtained within 12 hours after administration. It remains at therapeutic level for at least 7 days. Antibiotic is mainly excreted in urine (>70%) and partially in feces.
IndicationsUse Ceftisyl to treat cattle with bacterial respiratory infections, necrobacillosis, acute puerperal endometritis and other primary and secondary infections, agents of which are susceptible to ceftiofur.
ContraindicationsIncreased individual sensitivity to beta-lactam antibiotics. Do not use in combination with tetracyclines and levomycetin (due to decrease in drug bactericidal activity), aminoglycosides, furosemide and ethacrynic acid (due to potential increase in nephrotoxic effect).
AdministrationSingle subcutaneous administration near the base of ear. Dose is 1 ml per 30 kg of body weight (6.6 mg of ceftiofur per 1 kg of body weight). Maximum volume of drug to be administered in the same site is 30 ml.
If volume of the drug to be injected exceeds above listed dose, administer it in several sites. Before every use carefully shake a bottle with the drug.
Adverse eventsAdverse events and complications are not generally observed in case of administration as per package insert. Rarely an oedema may be observed in injection site which naturally disappears within several days. In case of increased individual sensitivity to cephalosporin antibiotics and allergic reactions, stop drug administration and use antihistaminic and symptomatic drugs. Overdose: potential dysorexia and inflammation of injection site.
Special warningsCattle are allowed to be slaughtered for meat not earlier than 20 days after the last drug administration. Meat of compulsorily slaughtered animals received before stated period termination can be used to feed fur animals. Milk of milking cows received during drug administration period is esculent without restriction.
StorageStore in closed original package. Protect from direct sunlight and moisture. Store separately from food and animal feeding at 2-30°С.
Shelf life is 2 years from manufacturing date when stored in closed original package in accordance with regulations and 28 days after the first bottle opening.
Pharmaceutical formThe drug is manufactured in 50/100 ml glass and polymeric bottles of appropriate volume.
The information provided in this catalog is for reference only. There may be some changes in the characteristics, packaging and packaging of products.
AVZ reserves the right to make such changes without notice. You can get full information about the updated products from your personal manager or your nearest AVZ dealer.
All drugs for veterinary use from this catalog may be contraindicated and when using it is necessary to familiarize yourself with the Instructions for Use.